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Finally, xanthine oxidase will oxidize hypoxanthine to xanthine (guanine can be deaminated to xanthine), and xanthine can be further oxidized to uric acid by the same enzyme

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In HER2-positive breast cancer, overactivation of HER2 upregulates SLC7A11 via the PI3K/AKT/mTOR pathway to increase the antioxidant capacity [85]

We further validated the ubiquitination of PPAR by NEDD4

In this step, clean data were obtained by removing reads containing adapters, reads containing poly-N, and low-quality reads from raw data

Cell counts of the population of interest was normalized by the beads counts acquired